HUMAN ASTROVIRUSES: A BRIEF REVIEW

M. Z. Pam, V. Omote

Abstract


Astroviruses belonging to the family Astroviridae are cosmopolitan and infect a wide range of mammalian and avian hosts. Human Astroviruses (classic HAstV) under the genera Mamastrovirus within eight (8) different serogroups are responsible for 2-9% of all acute nonbacterial gastroenteritis in children worldwide. Although its pathogenicity and pathogenesis are still poorly understood, attachment of the viral spike and capsid protein to intestinal epithelial cells activates a process which results in mal-absorption, loss of secretory functions, and reduced permeability. The possibility for cross-species transmission has raised alarm about possible zoonotic transmission. Thus, its biology, epidemiology, pathology, immunology, diagnosis and management are briefly reviewed.

Keywords: Human Astroviruses, epidemiology, pathology, immunology, diagnosis, management, interspecies transmission, zoonosis


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